Embedded Files
Our research seeks to understand how proteins that regulate nucleotide homeostasis and proteostasis enable human pathogens to survive, adapt, and proliferate. We combine protein biochemistry, biophysics, structural biology, and computational approaches to define how these proteins recognize substrates, control catalytic activity, and respond to cellular stress. By uncovering pathogen-specific mechanisms that differ from those in human cells, we aim to identify molecular vulnerabilities that can inform the development of new therapeutic strategies for infectious diseases.
Nucleotide Homeostasis and Proteostasis in Human Pathogens
Nucleotide Homeostasis and Proteostasis in Human Pathogens
The lab investigates two interconnected systems that are essential for pathogen survival: nucleotide homeostasis, which maintains the nucleotide pools required for nucleic acid synthesis and cellular metabolism, and proteostasis, which preserves protein folding, function, and quality control during stress. We study enzymes that regulate nucleotide metabolism and proteostasis systems that maintain protein stability and quality control.
Active engagement of undergraduate students
Active engagement of undergraduate students
90% of our team is made up of undergraduate students with a strong passion for research. We are always eager to welcome motivated, curious minds to the lab. For opportunities, please contact Dr. Graham Chakafana.
Protein Biochemistry
Structural Biology
Characterization of druggable protein targets
Proteomics & genomics of cardiac disease in minority populations
The Chaks lab is in the Biochemistry Dept. at Hampton University
The Chaks lab is in the Biochemistry Dept. at Hampton University
Page updated
Google Sites
Report abuse